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2008) VEGF exerts this effect by restoring blood flow in the nerves as well as by directly affecting Schwann cells (Thakur et al

With the continuous emergence of novel biologics and small molecules, clinical decision-making must integrate disease conditions, medical history, comorbidities, and safety considerations to develop precise sequential strategies [330, 331]

Building on these findings, integrating CUL5 modulation strategies with existing CAR-M (chimeric antigen receptor macrophage) therapies holds promise for developing next-generation engineered macrophages with enhanced tumor-killing capacity and microenvironment-remodeling abilities